Announcement PDF Form 604 Corporations Act 2001 Section 671B Notice of change of interests of substantial holder To: Company Name/Scheme MICROBA LIFE SCIENCES LIMITED (Microba) ACN/ARSN 617 096 652 1. Details of substantial holder (1) Name MICROBA LIFE SCIENCES LIMITED ACN/ARSN (if applicable) 617 096 652 There was a change in the interests of the substantial holder on 27/01/2024 The previous notice was given to the company on 28/11/2023 The previous notice was dated 27/11/2023 2. Previous and present voting power The total number of votes attached to all the voting shares in the company or voting interests in the scheme that the substantial holder or an associate (2)had a relevant interest (3) in when last required and when now required, to give a substantial holding notice to the company or scheme are as follows: Class of securities (4) Ordinary shares Previous notice Person's Voting power (5) 102,671,611 23.62% Present notice Person'svotes 48,171,314 Voting power (5) 10.76% 3. Changesin relevant interests Particulars of each change in, or change in the nature of a relevant interest of the substantial holder or an associate in voting securities of the company or scheme, since the substantial holder was last required to give a substantial holding notice to the company or scheme are as follows: Date of change Person whose relevant interest changed Nature of change (6) 6/12/2023 Microba Dilution due to issue of shares for the acquisition of Invivo Clinical Ltd 27/1/2024 Microba Release of securities from voluntary escrow Person's votes affected $2,826,753.43 Class and number of securities affected 13,141,578 Not applicable (54,500,297) (54,500,297) Consideration given in relation to change (7) 4. Present relevant interests Particulars of each relevant interest of the substantial holder in voting securities after the change are as follows: 13,141,578 Holder of relevant interest Microba Registered holder of securities Person entitled to be registered as holder(8) The holders listed in Annexure A The holders listed in Annexure A Nature of relevant interest (6) Class and number of securities 48,171,314 Relevant interest arising under ordinary shares section 608(1)(c) of the Corporations Act 2001 (Cth), being a relevant interest arising as a result of having control over the exercise of the power to dispose of the shares held by the persons that have entered into escrow arrangements with Microba, pursuant to the: • voluntary escrow deed; • mandatory ASX restriction deeds and notices; • Employee Share and Option Plan. Person's votes 48,171,314 5. Changesin association The persons who have become associates (2) of, ceased to be associates of, or have changed the nature of their association (9) with, the substantial holder in relation to voting interests in the company or scheme are as follows: Nameand ACN/ARSN(if applicable) N/A Nature of association 6. Addresses The addresses of persons named in this form are as follows: Name Microba Address Level 10, 324 Queen Street, Brisbane QLD 4000 Signature print name James Heath Capacity Company Secretary sign here Date: 4 March 2024 DIRECTIONS (1) If there are a number of substantial holders with similar or related relevant interests (eg. A corporation and its related corporations, or the manager and trustee of an equity trust), the names could be included in an annexure to the form. If the relevant interests of a group of persons are essentially similar, they may be referred to throughout the form as a specifically named group if the membership of each group, with the names and addresses of members is clearly set out inparagraph6of the form. (2) See the definition of "associate" insection9 of the Corporations Act 2001. (3) See the definition of "relevant interest" insections608and671B(7)of the Corporations Act 2001. (4) The voting shares of a company constitute one class unless divided into separate classes. (5) The person’s votes divided by the total votes in the body corporate or scheme multipliedby100. (6) Include details of: (a) any relevant agreement or other circumstances because of which the change in relevant interest occurred. If subsection671B(4)applies, a copy of any document setting out the terms of any relevant agreement, and a statement by the person giving full and accurate details of any contract, scheme or arrangement, must accompany this form, together with a written statement certifying this contract, scheme or arrangement; and (b) Any qualification of the power of a person to exercise, control the exercise of, or influence the exercise of, the voting powers or disposal of the securities to which the relevant interest relates (indicating clearly the particular securities to which the qualification applies). See the definition of "relevant agreement" in section 9 of the Corporations Act 2001. (7) Details of the consideration must include any and all benefits, money and other, that any person from whom a relevant interest was acquired has, or may, become entitled to receive in relation to that acquisition. Details must be included even if the benefit is conditional on the happening or not of a contingency. Details must be included of any benefit paid on behalf of the substantial holder or its associate in relation to the acquisitions, even if they are not paid directly to the person from whom the relevant interest was acquired. (8) If the substantial holder is unable to determine the identity of the person(eg. if the relevant interest arises because of an option)write "unknown". (9) Give details, if appropriate, of the present association and any change in that association since the last substantial holding notice. Information in this guide is intended as a guide only. Please consult your accountant or solicitor for further advice. Annexure A Holder of relevant interest Microba Registered holder of securities SA MICROBA HOLDINGS PTY LTD ACN 624 108 452 Person entitled to be registered as holder (8) SA MICROBA HOLDINGS PTY LTD ACN 624 108 452 Class and number of securities 18,524,277 Microba GENENIKA PTY LTD AS TRUSTEE OF THE TYSON TRUST MACROGEN INC GENENIKA PTY LTD AS TRUSTEE OF THE TYSON TRUST 17,100,000 MACROGEN INC 7,161,764 ROMBOLA FAMILY PTY LTD AS TRUSTEE FOR ROMBOLA FAMILY TRUST FRAZER SERVICES PTY LTD ACN 115 628 772 AS TRUSTEE FOR THE FRAZER FAMILY TRUST MARK CAPONE DERP ENTERPRISES PTY LTD ACN 619 696 034 AS TRUSTEE FOR THE ANGEL BARNETT FAMILY TRUST BLAKE ALAN WILLS AS TRUSTEE FOR THE PRIMROSE FAMILY TRUST PROJECT INSIGHT PTY LTD ACN 143 259 947 AS TRUSTEE FOR THE PROJECT INSIGHT TRUST AMANDA ANDERSON CASSANDRA BARNETT HOLLY B BAUZON JOEL BOYD TIMOTHY BROWNE TERRIE-ANNE COCK MARTHA COOPER MELODY DOBRININ TIMOTHY DWYER KYLIE ELLIS LIANG FANG CHARLOTTE FRIEDLANDER HARRISON GRAY BIANCA MAREE HARRINGTON ALEXANDER HASSON GORDON HAYLETT AREEJ ALSHEIKH HUSSAIN JAM DROPS PTY LTD MARIE KALKAUS LUTZ KRAUSE ANNIKA KRUEGER JEAN-PHILIPPE LAINE TIMOTHY LAMBERTON YAO LIU JEIMY JIMENEZ LOAYZA SAMANTHA MACDONALD KENNETH MCGRATH REBECCA MOREHOUSE XIN NA MICHAEL NISSEN BOZICA NYEVERECZ PARAIC O'CUIV HAYLEY PARCELL MARK PARKER ANDREA RABELLINO SAHANA RAJASHEKAR LUKE REID FABIO RIGATO ALENA RINKE KASRA SABERMANESH PERDEEP SINGH PAULA SMITH-BROWN CHRISTINE STEWART KRYSTYNA SULLIVAN MITCHELL SULLIVAN ANITA TAIT ROMBOLA FAMILY PTY LTD AS TRUSTEE FOR ROMBOLA FAMILY TRUST 4,500,000 FRAZER SERVICES PTY LTD ACN 115 628 772 AS TRUSTEE FOR THE FRAZER FAMILY TRUST 556,384 MARK CAPONE DERP ENTERPRISES PTY LTD ACN 619 696 034 AS TRUSTEE FOR THE ANGEL BARNETT FAMILY TRUST 188,889 Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba Microba BLAKE ALAN WILLS AS TRUSTEE FOR THE PRIMROSE FAMILY TRUST PROJECT INSIGHT PTY LTD ACN 143 259 947 AS TRUSTEE FOR THE PROJECT INSIGHT TRUST AMANDA ANDERSON CASSANDRA BARNETT HOLLY B BAUZON JOEL BOYD TIMOTHY BROWNE TERRIE-ANNE COCK MARTHA COOPER MELODY DOBRININ TIMOTHY DWYER KYLIE ELLIS LIANG FANG CHARLOTTE FRIEDLANDER HARRISON GRAY BIANCA MAREE HARRINGTON ALEXANDER HASSON GORDON HAYLETT AREEJ ALSHEIKH HUSSAIN JAM DROPS PTY LTD MARIE KALKAUS LUTZ KRAUSE ANNIKA KRUEGER JEAN-PHILIPPE LAINE TIMOTHY LAMBERTON YAO LIU JEIMY JIMENEZ LOAYZA SAMANTHA MACDONALD KENNETH MCGRATH REBECCA MOREHOUSE XIN NA MICHAEL NISSEN BOZICA NYEVERECZ PARAIC O'CUIV HAYLEY PARCELL MARK PARKER ANDREA RABELLINO SAHANA RAJASHEKAR LUKE REID FABIO RIGATO ALENA RINKE KASRA SABERMANESH PERDEEP SINGH PAULA SMITH-BROWN CHRISTINE STEWART KRYSTYNA SULLIVAN MITCHELL SULLIVAN ANITA TAIT 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 2,500 Microba Microba Microba Microba Microba Microba Microba KAYLYN TOUSIGNANT CHARLOTTE VIVIAN ANDREW WEBB TRISTAN WIMPENNY PATRICIA VERA WOLF DAVID WOOD YUSI ZHOU KAYLYN TOUSIGNANT CHARLOTTE VIVIAN ANDREW WEBB TRISTAN WIMPENNY PATRICIA VERA WOLF DAVID WOOD YUSI ZHOU 2,500 2,500 2,500 2,500 2,500 2,500 2,500