Announcement PDF ASX Announcement 19 November 2024 Bell Potter Healthcare Conference Presentation Microba Life Sciences Limited (ASX: MAP) (“Microba”), is pleased to announce that it will present at the Bell Potter Healthcare Conference 2024 today, Tuesday November 19 2024, at 2:00pm AEDT (Sydney/Melbourne) / 1:00pm (Brisbane). Microba CEO, Dr Luke Reid will deliver the presentation. Shareholders, investors and interested parties are encouraged to register and attend the presentation at the following link: https://extraconnect.co/bell-potter-healthcare-2024-ext/ A copy of the presentation is attached to this announcement. View this announcement and presentation on our Investor Hub: https://ir.microba.com/link/WPGmRe This announcement has been authorised for release by the Chair and Chief Executive Officer. For further information, please contact: Dr Luke Reid Chief Executive Officer luke.reid@microba.com Investor / Media Relations investor@microba.com https://ir.microba.com/welcome About Microba Life Sciences Limited Microba Life Sciences is a precision microbiome company driven to improve human health. With world-leading technology for measuring the human gut microbiome, Microba is driving the discovery and development of novel therapeutics for major chronic diseases and delivering gut microbiome testing services globally to researchers, clinicians, and consumers. Through partnerships with leading organisations, Microba is powering the discovery of new relationships between the microbiome, health and disease for the development of new health solutions. For more information visit www.microba.com JOIN MICROBA’S INTERACTIVE INVESTOR HUB For more Company information and to engage with management by asking questions about Microba’s latest announcements and updates, visit ir.microba.com/welcome Microba Life Sciences Ltd | ABN 82 617 096 652 | L10, 324 Queen Street, Brisbane QLD 4000 Australia | 1300 974 621 At the forefront of microbiome diagnostics & therapeutics Bell Potter Healthcare Conference 2024 ASX: MAP 19 November 2024 Authorised for release by the Chair and the CEO Disclaimer This presentation (Presentation) has been prepared by Microba Life Sciences Limited (Microba). Summary information - This Presentation contains summary information about Microba and its activities which is current only as at the date of release of this Presentation. Microba may in its absolute discretion, but without being under any obligation to do so, update or supplement this Presentation. The information in this Presentation is of a general nature and does not purport to be complete nor does it contain all the information which a prospective investor may require in evaluating a possible investment in Microba or that would be required in a prospectus or other disclosure document prepared in accordance with the requirements of the Corporations Act 2001 (Cth) (Corporations Act). Industry and market data – In this Presentation, Microba refers to certain market, industry, and statistical data used in connection with this Presentation may have been obtained from research, surveys or studies conducted by third parties, including industry or general publications. Neither Microba nor its representatives have independently verified any such data and no representation or warranty, express or implied, is made as to its fairness, accuracy, correctness, completeness or adequacy. 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Forward-looking statements generally relate to current expectations, hopes, beliefs, intentions, strategies or productions about future events or Microba's future financial or operating performance. For example, statements regarding anticipated growth in the industry in which Microba operates and anticipated growth in demand for Microba's products and services, projections of Microba's future financial results and other metrics are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as "pro forma", "may", "should", "could", "might", "plan", "possible", "project", "strive", "budget", "forecast", "expect", "intend", "will", "estimate", "anticipate", "believe", "predict", "potential" or "continue", or the negatives of these terms or variations of them or similar terminology, but the absence of these words does not mean that a statement is not forwardlooking. 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The forward looking statements in this Presentation are based on information available to Microba as at the date of this Presentation and nothing in this Presentation should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved. Except as required by law or regulation, Microba undertakes no obligation to provide any additional or updated information whether as a result of new information, future events or results or otherwise. Financial data – All dollar values in Australian dollars (A$ or $) unless otherwise stated. Recipients should note that this Presentation contains historical and pro-forma financial information. Any financial information provided in this Presentation is for illustrative purposes only and is not represented as being indicative of Microba’s views on its future financial condition and/or performance. Trademarks – This Presentation may contain trademarks, trade names and copyrights of other companies, which are the property of their respective owners. Solely for convenience, some of the trademarks, trade names and copyrights referred to in this Presentation may be listed without the © or ® symbols, but Microba asserts, to the fullest extent under applicable law, the rights of the applicable owners, if any, to these trademarks, trade names and copyright. Disclaimer - Except for any statutory liability which cannot be excluded, Microba, its related bodies corporate and their respective officers, employees and advisers expressly disclaim all liability (including negligence) for any direct or indirect loss or damage which may be suffered by any person in relation to, and take no responsibility for, any information in this Presentation or any error or omission therefrom, and make no representation or warranty, express or implied, as to the currency, accuracy, reliability or completeness of this Presentation. 2 Unequivocal evidence demonstrates that the human gut microbiome is a critical component of disease >21,000 Research publications demonstrate a clear link between chronic diseases and the gut microbiome1 1 PubMed search terms "gut microbiome/microbiota" or "stool microbiome/microbiota" or "faecal microbiome/microbiota" and "disease" 3 Changing the microbiome can change disease outcomes >150 Global clinical studies demonstrate that microbiome modulation can influence disease outcomes and clinical symptoms1 Infectious Disease Inflammatory Disease Autoimmune Disease Cancer Mental Health Metabolic Disorders Heart Disease Neurodegenerative Disease 1 PubMed search terms "gut microbiome" and "modulate" and "clinical study" and manually selecting for clinical trials with positive results indicated in the abstracts. 4 Company snapshot TESTING/ DIAGNOSTICS THERAPEUTICS 5 Continuous YoY revenue growth over 6 years of operations 2 diagnostic products opening a new category with an estimated US$15B addressable market in the USA alone Partnerships with market leaders incl. Sonic Healthcare (ASX: SHL), SYNLAB (GR:SYAB) + more Clinical stage therapeutic lead candidate advancing to Phase 2 clinical trial World-class team 6 Our diagnostics vision: To combat disease through microbiome health 7 Our diagnostics focus Patients suffering from gastrointestinal disease → Gastrointestinal Mental Cardiovascular Oncology Longevity Fertility Gastrointestinal Disease Half of patients are not getting a resolution 37,310,000 Patients presenting annually in the US with lower GI abdominal symptoms* 21,500,000 Pain, bloating, other 15,370,000 53% Resolved 8 47% Unresolved Diarrhoea 440,000 IBD % of patients achieving resolution of gastrointestinal symptoms after 5 years** * Assessment of Medicare claims analysis. Estimated Private and Medicaid numbers extrapolated from Medicare claims analysis completed with Boston based MedTech specialist consultancy Veranex Inc. ** Gordon, J., Miller, G., & Valenti, L. (2015). The management of unresolved gastrointestinal symptoms in Australian general practice. Australian Family Physician, 44(9), 621-623 *** Addressing the GI symptom challenge Microba’s comprehensive diagnostic products First line Diagnosing pathogenic causes of GI symptoms Gastrointestinal pathogen test Launched March 2024  Stool DNA test.  175 targets.  Expertly curated clinical recommendations for targeted treatment. Second line Identifying functional causes and treatment options for non-pathogenic GI symptoms Gastrointestinal disorder test Launched February 2023  Stool DNA + targeted biomarker test.  7 functional GI markers. >28k microbiome markers.  Expertly curated clinical recommendations for personalised treatment. 9 Getting answers for patients in need Closing the gap on GI symptom diagnosis and treatment 100% 47% 28% new insights with * 50% ** 24% new diagnoses with Unresolved ** 0% % of patients achieving resolution of gastrointestinal symptoms after 5 years 52% receiving critical new diagnoses and treatment recommendation for these patients. * Study of first 17 months of MetaXplore test results in clinical practice in Australia ** Study of first 4 months of MetaPanel test results in clinical practice in Australia 10 A multi-billion dollar diagnostics market opportunity $15B+ USA Total Addressable Market* * Assessment of Medicare claims analysis. Estimated Private and Medicaid numbers extrapolated from Medicare claims analysis completed with Boston based MedTech specialist consultancy Veranex Inc. Assumes minimum revenue per test of US $416.78 aligned to CPT code 57507. This is viewed to be the minimum with the top pricing predicate at US $2126.20 11 Changing lives every day “I have struggled with gastrointestinal symptoms for over half my life. I have tried resolving with many specialists, restrictive eating plans and natural therapies. My MetaXplore test this year identified clear problems and a personalised treatment plan. I am grateful that through following the treatment plan I have achieved complete resolution to my symptoms and can enjoy eating unrestricted for the first time in 35 years.” MetaXplore patient, South Australia 12 13 Our diagnostics traction Growing MetaXplore sales and clinical adoption in Australia MetaXplore Test Sales Volume 14 MetaXplore Ordering Clinicians 723 2,935 436 1,832 984 181 H2 FY23 H1 FY24 Australia H2 FY24 Q1 FY25 H2 FY23 H1 FY24 H2 FY24 1,832 tests sold, up 101% vs PCP. • 487 1,841 • Q1 FY25 Strong start to Q2 with October a record sales month • 487 ordering clinicians, up 81% vs PCP • Growth activities: - Targeted sales and marketing activities focused on high prescribing potential clinicians - Clinician education - KOL engagement - Utility studies and publications MetaPanel sales building across Australia Australia • Doctor referrals and sales continuing to build monthly across the country, focused around the major east coast states New South Wales, Victoria and Queensland. • Assoc. Prof. Michael Wehrhahn from Douglass Hanly Moir (Sonic Healthcare NSW) presented at Gastroenterology Week 2024 . The leading event of the year for Gastroenterologists. • Growth activities: - Targeted sales and marketing activities focused on gastroenterology specialists and general practice - Clinician education - KOL engagement - Utility studies and publications 15 Transitioning to growth in the United Kingdom The fundamental investment thesis of the Invivo Clinical acquisition was the ability to accelerate Microba’s entry of it’s world leading MetaXplore test into the United Kingdom through an established team and customer base. The UK market demand and anticipation for access to MetaXplore has been compelling since the acquisition was announced. “From our leading position in market, we expect Microba’s world leading MetaXplore will become the most favoured microbiome test for healthcare professionals in the UK” Quote from Invivo Head of Clinical Innovation United Kingdom The team have now commenced MetaXplore access in the UK in October with first orders already received, setting up for full market access in 2025. Supporting the UK growth strategy, the Invivo sales force was doubled at the end of the quarter. This focus and investment are expected to translate into growth in H2 FY25. 16 Q1 Financial Highlights 17 Record Q1 revenue, strong sales momentum in Australia, primed for UK growth Revenue by Quarter Record Q1 revenue, with MetaXplore adoption and revenue continuing to accelerate in Australia $6,000,000 +239% $5,000,000 • $4,000,000 $3,000,000 $2,000,000 MetaXplore sales commenced in the UK in October, with first orders already received $1,000,000 $- offsetting the historical impact of seasonal softness due to holiday periods in both northern and southern hemispheres impacting Q1 vs Q4 Q4FY23 Q1FY24 Q2FY24 Q3FY24 Q4FY24 Q1FY25 Accelerating growth through strategic appointments Eric Davis Chief Growth Officer 18 Chris Saad Chief Product Officer 19 Our therapeutics vision To combat disease through microbiome health 19 20 Our primary therapeutic focus Clinical: Patients suffering from Inflammatory Bowel Disease Autoimmune Oncology Allergy Neuro Cardiovascular → Gastrointestinal 20 21 Therapeutic Development Programs continue to advance Core Program IBD (Ulcerative Colitis) Discovery R&D Undisclosed (LBP) Preclinical Phase 1 Phase 2 • Inflammatory Bowel Disease Program - Advancing MAP315 to Phase 2. • Immuno-Oncology Program - Clinical data and sample set grown to >4,500 patients supporting this program. • Autoimmune Program - Generated pre-clinical data supporting lead activity. MAP 315 (LBP) Immunooncology Undisclosed (LBP) Autoimmune Undisclosed (LBP) LBP = Live Biotherapeutic Product 21 Recent IBD Transactions Stage Upfront Total Deal Value Acquisition Phase 2 - US$3.2B June 2024 License Preclinical $150m US$1.7B October 2023 Acquisition Phase 2 - US$7.2B October 2023 License Phase 2b $500m US$1.5B Apr 2023 Acquisition Phase 2A - US$10.8B Date Deal Type July 2024 Licensee / Acquiror 22 Licensor / Target active complete active complete https://www.reuters.com/markets/deals/eli-lilly-acquire-morphic-holding-32-billion-2024-07-08/ , https://www.reuters.com/business/healthcare-pharmaceuticals/abbvie-inks-immune-disorder-drug-licensingdeal-with-chinas-futuregen-2024-06-13/ , https://investor.roivant.com/news-releases/news-release-details/roche-enters-definitive-agreement-acquire-telavant-including , https://www.sanofi.com/en/mediaroom/press-releases/2023/2023-10-04-05-00-00-2754288 , https://www.merck.com/news/merck-completes-acquisition-of-prometheus-biosciences-inc/ 22 23 Key areas of focus Financial Snapshot Diagnostics  Australia - diagnostic sales growth and clinical adoption  United Kingdom - diagnostic test launch  United States - US reimbursement path Therapeutics  IBD therapeutic Phase 2 trial  Therapeutic asset partnering 1 At 18 November 2024 | 2 At 30 June 2024 ASX Code MAP Market capitalisation1 $72m Shares on issue 447.85m $0.145 / $0.23 52-week low / high1 Cash Balance (30 Sep 2024) $16.4m R&D Tax Incentive Refund (Received 15 Nov 24) $6m Major Shareholders Shareholder Ownership %2 Sonic Healthcare 19.14% Perennial 14.32% SA Microba Holdings 7.48% Thorney Investment Group 6.69% Macrogen 3.98% Philip Hugenholtz 3.84% Gene Tyson 3.82% JOIN MICROBA’S INTERACTIVE INVESTOR HUB Dr Luke Reid Chief Executive Officer luke.reid@microba.com Visit ir.microba.com/welcome for Microba’s interactive Investor Hub CONTACT Head Office Level 10, 324 Queen Street Brisbane QLD Australia Laboratory Princess Alexandra Hospital Woolloongabba QLD Australia